Down Syndrome (DS) Rodent Models: Comprehensive Reference

📋 Behavioral Phenotyping & ARRIVE Guidelines: Researchers using these models should follow the DS-specific behavioral phenotyping protocols and ARRIVE reporting standards described in Roper et al. (2020), Current Protocols in Mouse Biology, 10, e79 . Full protocols and guidelines are available in the GitHub repository .

📄 Publication & Database Citation: This database and associated Github repository are published in: Raza, M., Folz, A., Victorino, D., et al. (2026). A researcher’s guide to rodent models of Down syndrome: Recent insights and translational perspectives. STAR Protocols, 7. https://doi.org/10.1016/j.xpro.2026.104717

📚 Original Dataset Source: The core dataset was originally compiled and then updated from: Folz, A., Sloan, K., & Roper, R. J. (2025). Mouse models of Down syndrome. In B. Ye & R. Reeves (Eds.), Genetic Models of Down Syndrome. Springer, Cham. https://doi.org/10.1007/978-3-031-78611-2_1

All coordinates based on Mouse GRCm39 and Human GRCh38 unless otherwise noted. This excludes the non-transchromosomic Rat models.

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Approved Name/ID ⇅	Lab/Common Name ⇅	Type of DS Model ⇅	Short Description	Genetic Background ⇅	Genomic Coordinates	Number of Hsa 21 orthologs (dosage imbalance; excluding Krtap genes) ⇅	First Publication	Availability	RRID/Source ⇅

*Note: Tc1 count includes duplications and anticipated single copy genes.
**Note: TcMAC21 and TcHSA21rat HSA21 coordinates are reported on Human GRCh38/RefSeq NC_000021.9; WGS mapping in Kazuki et al. used GRCh38.p13 Primary Assembly.